|英文名称||Heparin sodium salt|
|英文别名||Sodium heparin;Sodium heparinate;Heparin sodium;Deligoparin sodium; Minolteparin sodium; Nadroparine sodium|
· Heparin sodium salt from porcine intestinal mucosa has been used in sLRP (soluble circulating low density lipoprotein receptor-related protein-1) purification from human plasma.
· It has been used as a supplement in M199 medium for culturing of human umbilical vein endothelial cells.
· It has been used as an anticoagulant agent during isolation of blood.
|规格或纯度||185 USP units/mg|
|生化机理||Heparin, Sodium salt is a low molecular weight heparin (LMWH) polymer that produces its major anticoagulant effect by activating antithrombin. This activation causes a conformational change in ATIII and allows for increased flexibility in its reactive site loop. Heparin is a highly sulfated glycosaminoglycan known for preventing clots. Heparin, Sodium Salt is also an activator of RyR and ATIII.|
Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.
A heparin polymer that produces its anticoagulant effect by activating ATIII (antithrombin).
|溶解性||Soluble in water (100 mg/ml), DMSO (< 1 mg/ml), and ethanol (< 1 mg/ml).|