Anti-Substance P Receptor Antibody, pain
货 号：AB5060
产品规格：50ul
原 产 地：Chemicon
参考价格：4107 （参考价格，以实际价格为准）
优惠价格：3171
Anti-Substance P Receptor Antibody, pain AB5060
Species Reactivity Key Applications Host Format Antibody Type
R, Gp, M WB, IF, IHC Rb Serum Polyclonal Antibody
Catalogue Number AB5060
Brand Family Chemicon®
Synonyms NK-1 Receptor
Trade Name
Chemicon
Description Anti-Substance P Receptor Antibody, pain
Background Information Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Product Information
Format Serum
Specificity Specific for the Substance P Receptor (NK-1).
Control
Spinal Cord, brain membrane lysate
Presentation Rabbit polyclonal serum in buffer containing liquid with no preservatives.
Applications
Application Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Key Applications
Western Blotting
Immunofluorescence
Immunohistochemistry
Application Notes Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen species Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
Epitope C terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Specific for the Substance P Receptor (NK-1).
Species Reactivity Rat Guinea Pig Mouse
Species Reactivity Note Rat, mouse and guinea pig.
Antibody Type Polyclonal Antibody
Entrez Gene Number
NM_003182.1
Entrez Gene Summary This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.
产品详细信息
Anti-Substance P Receptor Antibody, pain AB5060
Species Reactivity Key Applications Host Format Antibody Type
R, Gp, M WB, IF, IHC Rb Serum Polyclonal Antibody
Catalogue Number AB5060
Brand Family Chemicon®
Synonyms NK-1 Receptor
Trade Name
Chemicon
Description Anti-Substance P Receptor Antibody, pain
Background Information Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Product Information
Format Serum
Specificity Specific for the Substance P Receptor (NK-1).
Control
Spinal Cord, brain membrane lysate
Presentation Rabbit polyclonal serum in buffer containing liquid with no preservatives.
Applications
Application Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Key Applications
Western Blotting
Immunofluorescence
Immunohistochemistry
Application Notes Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen species Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
Epitope C terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Specific for the Substance P Receptor (NK-1).
Species Reactivity Rat Guinea Pig Mouse
Species Reactivity Note Rat, mouse and guinea pig.
Antibody Type Polyclonal Antibody
Entrez Gene Number
NM_003182.1
Entrez Gene Summary This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.