NK1R抗体
货 号：sc-5218
产品规格：200 µg/ml
原 产 地：santa
参考价格：2400 （参考价格，以实际价格为准）
优惠价格：
The substance P receptor, also designated NK-1R for neurokinin 1 receptor, is a member of a class of tachykinin receptors which also includes the NK-2 receptor and the NK-3 receptor (1,2). Substance P receptors bind to tachykinin peptides, including substance P, substance K and neuromedin K. NK-1R is likely to be involved in nociceptive transmission, basal ganglia function or anxiety and depression (2). NK-1R is expressed in a high proportion of spinothalmic and spinobranchial neurons located in lamina 1 (3). NK-1R neurons in the dorsal horn of the spinal cord may play a role in chronic neuropathic and inflammatory pain (4). Ligand-induced internalization of NK-1R into early endosomes deplete the cell surface of these receptors. This internalization may be involved in a down-regulation response of a cell to substance P (5,6).
NK-1R Antibody (N-19) Product Citations
Lim, YY. et al. 2012. A comparison of neuropeptide expression in skin with allergic contact dermatitis in human and mouse. Int. J. Dermatol. 51: 939-946. View PubMed Entry
Strell, C. et al. 2009. Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes. BMC Immunol. 10: -. View PubMed Entry
Mathers, A. et al. 2007. In Vivo Signaling through the Neurokinin 1 Receptor Favors Transgene Expression by Langerhans Cells and Promotes the Generation of Th1- and Tc1-Biased Immune Responses. J. Immunology. 178: 7006-7017. View PubMed Entry
Ravina, CG. et al. 2007. A role for tachykinins in the regulation of human sperm motility. Hum. Reprod. 22: 1617-1625. View PubMed Entry
Zee, E.D. et al. 2006. Hypoxia upregulates lung microvascular neurokinin-1 receptor expression. Am J Physiol Lung Cell Mol Physiol. . 291: L102-L110. View PubMed Entry
产品详细信息 NK-1R Antibody (N-19) NK1R抗体 sc-5218
The substance P receptor, also designated NK-1R for neurokinin 1 receptor, is a member of a class of tachykinin receptors which also includes the NK-2 receptor and the NK-3 receptor (1,2). Substance P receptors bind to tachykinin peptides, including substance P, substance K and neuromedin K. NK-1R is likely to be involved in nociceptive transmission, basal ganglia function or anxiety and depression (2). NK-1R is expressed in a high proportion of spinothalmic and spinobranchial neurons located in lamina 1 (3). NK-1R neurons in the dorsal horn of the spinal cord may play a role in chronic neuropathic and inflammatory pain (4). Ligand-induced internalization of NK-1R into early endosomes deplete the cell surface of these receptors. This internalization may be involved in a down-regulation response of a cell to substance P (5,6).
NK-1R Antibody (N-19) Product Citations
Lim, YY. et al. 2012. A comparison of neuropeptide expression in skin with allergic contact dermatitis in human and mouse. Int. J. Dermatol. 51: 939-946. View PubMed Entry
Strell, C. et al. 2009. Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes. BMC Immunol. 10: -. View PubMed Entry
Mathers, A. et al. 2007. In Vivo Signaling through the Neurokinin 1 Receptor Favors Transgene Expression by Langerhans Cells and Promotes the Generation of Th1- and Tc1-Biased Immune Responses. J. Immunology. 178: 7006-7017. View PubMed Entry
Ravina, CG. et al. 2007. A role for tachykinins in the regulation of human sperm motility. Hum. Reprod. 22: 1617-1625. View PubMed Entry
Zee, E.D. et al. 2006. Hypoxia upregulates lung microvascular neurokinin-1 receptor expression. Am J Physiol Lung Cell Mol Physiol. . 291: L102-L110. View PubMed Entry