PtdIns-（4）-P1（1,2-二辛酰基）（铵盐）

磷脂酰肌醇（PtdIns）磷酸酯占总膜磷脂的一小部分，但它们在细胞信号的产生和传递中起着至关重要的作用。PtdIns-（4）-P1 1,2-二辛酰基）是天然PtdIns的合成类似物，在sn-1和sn-2位置具有饱和C8：0脂肪酸。该化合物包含与天然化合物相同的肌醇和二酰基甘油（DAG）立体化学。可以将PtdIns-（4）-P1磷酸化为二磷酸（PtdIns-P2; PIP2）和三磷酸酯（PtdIns-P3; PIP3）。磷酸肌醇（PI）特异性磷脂酶C水解PtdIns-（4,5）-P2生成肌醇三磷酸酯（IP3

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.