丹磺胺
基本信息
| 产品名称 | 丹磺胺 |
|---|---|
| 英文名称 | Dansylcadaverine |
| 别名 | 丹酰尸胺；N-（二甲基氨基萘磺酰）-1，5-戊二胺；N-（5-氨基戊基）-5-二甲基氨基萘-1-磺酰胺 |
| 英文别名 | N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, Monodansyl cadaverine, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine |
| 应用 | A fluorescent amine probe Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used: · as an endocytosis inhibitor in human proximal tubular HK-2 cells, mouse J774A.1 macrophages and human A549 epithelial cells · to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies · in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples |
| 规格或纯度 | ≥97% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | 自发荧光染料丹酰尸胺或单丹磺酰尸胺（MDC）通常用于监测自噬。 由于离子捕获和与膜脂质的特异性相互作用的组合，单丹磺酰尸胺优先在自噬泡中积累。 |
一般描述
Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. Dansylcadaverine functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throμghout. It is known that the specificity of Dansylcadaverine towards mammalian autophagosomes is due to ion trapping throμgh the acidic compartments of autophagosomes. In addition, Dansylcadaverine has biological applications in measuring cardiac autophagic flux, studying Parkinson’s disease, peritoneal ovarian tumor dissemination, and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles, which requires a brief exposure to the compound compared to previous methods.A fluorescent amine probe
Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. Dansylcadaverine functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throughout. It is known that the specificity of Dansylcadaverine towards mammalian autophagosomes is due to ion trapping through the acidic compartments of autophagosomes. In addition, Dansylcadaverine has biological applications in measuring cardiac autophagic flux, studying Parkinson’s disease, peritoneal ovarian tumor dissemination, and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles, which requires a brief exposure to the compound compared to previous methods.
A fluorescent amine probe
相关属性
| CAS编号 | 10121-91-2 |
|---|---|
| 敏感性 | 对空气敏感 |
| 溶解性 | 10 mg/mL Methanol |
| 储存温度 | -20°C储存,充氩 |
| MDL号 | MFCD00042704 |
| 分子量 | 335.464 |
| 分子式 | C17H25N3O2S |
| EC号 | 233-326-9 |
| 品牌 | Jinpan |
| PubChem CID | 4247 |