N,N-二去甲基-O-去甲基-(外消旋-文拉法辛)葡萄糖醛酸

N,N-二去甲基-O-去甲基-(外消旋-文拉法辛)葡萄糖醛酸

文拉法辛的代谢产物

有货

N,N-二去甲基-O-去甲基-(外消旋-文拉法辛)葡萄糖醛酸

品牌:Jinpan
N,N-Didesmethyl-O-desmethyl-(rac-Venlafaxine) Glucuronide

MSDS

质检证书(CoA)

相似产品

  • 分子式 C₂₀H₂₉NO₈
  • 分子量411.45

货号 (SKU) 包装规格 是否现货 价格 数量
N390704-1mg 1mg 期货 N,N-二去甲基-O-去甲基-(外消旋-文拉法辛)葡萄糖醛酸  

基本信息

产品名称 N,N-二去甲基-O-去甲基-(外消旋-文拉法辛)葡萄糖醛酸
英文名称 N,N-Didesmethyl-O-desmethyl-(rac-Venlafaxine) Glucuronide
运输条件 超低温冰袋运输

一般描述

N,N-去甲基-O-去甲基-(外消旋-文拉法辛)葡糖苷酸是文拉法辛的代谢产物。文拉法辛是苯乙胺的衍生物,据报道可通过阻止神经胺如5-羟色胺(5-羟色胺; 5-HT)和去甲肾上腺素(去甲肾上腺素)的突触前再摄取来促进中枢神经系统内的神经传递。还报道了文拉法辛 是多巴胺再摄取的弱抑制剂。|体外研究表明,文拉法辛 对毒蕈碱,组胺能或α-1肾上腺素受体没有明显的活性。据报道,文拉法辛的代谢是通过细胞色素P450(CYP)酶CYP2D6发生的,产生O-去甲基文拉法辛。CYP3A4产生较少的代谢产物N-去甲基文拉法辛

N,N-Didesmethyl-O-desmethyl-(rac-Venlafaxine) Glucuronide is a metabolite of Venlafaxine (sc-201102). Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake.|In vitro|studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.
N,N-Didesmethyl-O-desmethyl-(rac-Venlafaxine) Glucuronideis a metabolite of Venlafaxine

相关属性

熔点 >190° C (dec.)
溶解性 Soluble in methanol, and water.
储存温度 -20°C储存
分子量 411.45
分子式 C₂₀H₂₉NO₈
品牌 Jinpan