Anti-Substance P Receptor Antibody, pain

货　　号：AB5060

产品规格：50ul

原  产  地：Chemicon

参考价格：4107 （参考价格，以实际价格为准）

优惠价格：3171

Anti-Substance P Receptor Antibody, pain AB5060

Species Reactivity    Key Applications    Host    Format    Antibody Type
R, Gp, M    WB, IF, IHC    Rb    Serum    Polyclonal Antibody
Catalogue Number     AB5060
Brand Family     Chemicon®
Synonyms     NK-1 Receptor
Trade Name     

    Chemicon

Description     Anti-Substance P Receptor Antibody, pain
Background Information     Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Product Information
Format     Serum
Specificity     Specific for the Substance P Receptor (NK-1).
Control     

    Spinal Cord, brain membrane lysate

Presentation     Rabbit polyclonal serum in buffer containing liquid with no preservatives.
Applications
Application     Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Key Applications     

    Western Blotting
    Immunofluorescence
    Immunohistochemistry

Application Notes     Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.

Western Blot Analysis:
A previous lot was used at 1:500 dilution.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen species     Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
Epitope     C terminus
Concentration     Please refer to the Certificate of Analysis for the lot-specific concentration.
Host     Rabbit
Specificity     Specific for the Substance P Receptor (NK-1).
Species Reactivity     Rat Guinea Pig Mouse
Species Reactivity Note     Rat, mouse and guinea pig.
Antibody Type     Polyclonal Antibody
Entrez Gene Number     

    NM_003182.1

Entrez Gene Summary     This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.